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CANTAB

Alzheimer’s disease

For Alzheimer’s disease we recommend two options of test batteries, depending on whether you are looking at prodromal states or mild to moderate Alzheimer’s disease.

Our Alzheimer’s test batteries identify baseline impairment in Alzheimer’s disease with large effect sizes1, our tests discriminate the cognitive profile of MCI from Alzheimer’s disease and depression2,3 and are highly sensitive to disease progression2

The batteries tie in closely with current neurobiological models of Alzheimer’s disease, exhibiting sensitivity to under-activation of the hippocampus in MCI5. The tests also offer considerable advantage over traditional measures (ADAS-cog, MMSE) for predicting and discriminating stable from deteriorating forms of suspected dementia at an individual level6-9. Our Alzheimer’s testing batteries are clinically relevant as cognitive impairments in our tests correlate with everyday function and long-term outcomes in Alzheimer’s disease.

Measures

  • Motor skills
  • Executive function
  • Episodic memory
  • Visual memory
  • Information processing
  • Sustained attention

CANTAB Tests

Prodromal Alzheimer’s and MCI
Mild to Moderate Alzheimer’s disease

Additional assessments (optional)

Research

CANTAB has been shown to be highly sensitive to cognitive dysfunction in Alzheimer's disease, showing clinically meaningful outcomes associated with impaired day-to-day function1.

Internal data; see also Swainson et al., Dement Geriatr Cogn Disord, 2001

Key references

Barnett JH, Lewis L, Blackwell AD, Taylor M. Early intervention in Alzheimer's disease: a health economic study of the effects of diagnostic timing. BMC Neurol. 2014 May 7;14:101.

Chamberlain SR, Blackwell AD, Nathan PJ, Hammond G, Robbins TW, Hodges JR, Michael A, Semple JM, Bullmore ET, Sahakian BJ. Differential cognitive deterioration in dementia: a two year longitudinal study. J Alzheimers Dis. 2011;24(1):125-36.

Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR. Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;17(1-2):42-8.

Swainson R, Hodges JR, Galton CJ, Semple J, Michael A, Dunn BD, Iddon JL, Robbins TW, Sahakian BJ. Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks. Dement Geriatr Cogn Disord. 2001 Jul-Aug;12(4):265-80

Read published research using CANTAB in Alzheimer’s disease in our Bibliography


  1. Égerházi A, Berecz R, Bartók E, Degrell I. Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer’s disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2007;31(3):746–751. 
  2. Chamberlain et al., J Alz Dis, 2011. Chamberlain R., Wengenack T. M., Poduslo J. F., Garwood M., Jack C. R. (2011). Magnetic resonance imaging of amyloid plaques in transgenic mouse models of Alzheimer's disease. Curr. Med. Imaging Rev. 7, 3–7. 10.2174/157340511794653522 
  3. Swainson R, Hodges JR, Galton CJ, Semple J, Michael A, Dunn BD, et al. Early detection and differential diagnosis of Alzheimer’s disease and depression with neuropsychological tasks. Dement Geriatr Cogn Dis 2001; 12: 265-80
  4. M. de Rover , V.A. Pironti , J.A. McCabe , J. Acosta-Cabronero , F.S. Arana , S. Morein-Zamir , & B.J. Sahakian (2011). Hippocampal dysfunction in patients with mild cognitive impairment: A functional neuroimaging study of a visuospatial paired associates learning task. Neuropsychologia, 49(7), 2060–2070.
  5. Fowler, K. S., Saling, M. M., Conway, E. L., et al (1997) Computerized neuropsychological tests in the early detection of dementia: prospective findings. Journal of the International Neuropsychological Society, 3, 139–146.
  6. KS, Saling MM, Conway EL, Semple JM, Louis WJ. Paired associate performance in the early detection of DAT. J Int Neuropsychol Soc 2002; 8: 58–71.
  7. De Jager C, Blackwell A, Budge M, Sahakian B. Predicting cognitive decline in healthy adults. Am J Geriatr Psychiatry. 2005;13:735–740
  8. Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR. Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease. Dement Geriatr Cogn Disord 2004; 17: 42–48.