Blog
The BUMP Study: Using digital tools to gain a deeper understanding of pregnancy symptoms
Earlier this year, members of the Cambridge Cognition team were co-authors on a paper describing a protocol for the Better Understanding the Metamorphosis of Pregnancy (BUMP) study. This study, led by 4YouandMe, is aiming to use digital tools, some of which are provided by Cambridge Cognition, to gain a deeper understanding of the symptoms of pregnancy. Here, we explain the study's aims and why it is important. You can find the full paper here.
Measuring Health-Related Quality of Life with Multimodal Data
In July 2021, I was part of a workshop that discussed how digital measurement of multiple modalities could be used to assess Quality of Life. A paper detailing the findings of the workshop was published in May 2022. The findings are summarised here.
Acoustic features of voice as a measure of cognitive load during performance of serial subtraction i
Director of Research & Innovation, Francesca Cormack, presented acoustic features of voice as a measure of cognitive load during performance of serial subtraction in a remote data collection context at AAIC 2021.
Read on for the key findings and full poster.
Feasibility of Repeated Administration of Automated Verbal-Paired-Associate Memory in Older Adults
At AAIC 2021, Alex Kaula - R&D Scientist, hosted an interactive poster session on: Feasibility of Repeated Administration of Automated Verbal-Paired-Associate Memory in Older Adults
Read on for the key findings and full poster.
Adherence to a Six-Week Study of Wearable Digital Mood and Cognitive Assessments in Depression
At the 2021 SOBP Annual Meeting, our Director of Research & Innovation, Francesca Cormack hosted an interactive poster session on Adherence to a Six-Week Study of Wearable Digital Mood and Cognitive Assessments in Depression: Qualitative Insight
Read on for the key findings and full poster.
Validation of a Smartphone-based Digit Symbol Substitution Task in Participants With Major Depressio
At the virtual ISCTM - Annual Scientific Meeting, Luke Allen presented data supporting the validity of Smartphone-based DSST for assessments in patient populations such as MDD.
Read on for the key findings and the full poster: Validation and Comparability of Smartphone-based Digit Symbol Substitution Task with Written Version.
Lessons learned delivering virtual trials during Covid-19
Digital health expert Dr Jordan Brayanov from Takeda Pharmaceuticals shares his lessons learned delivering virtual trials during Covid-19 and predictions on what’s next for the industry.
Digital Health Event 2020 | Key takeaways from the industry experts
Industry experts working at the forefront of drug development, devices and digital health shared their lessons learned delivering virtual trials during the Covid-19 pandemic at Cambridge Cognition’s fourth annual Digital Health Event. Catch up on the key takeways from this thought-leading discussion.
Accuracy of automated scoring of verbal paired associates in a remote data collection context
At the virtual AAIC 2020 conference Dr Francesca Cormack shared her research, focusing on automatic speech recognition for verbal cognitive testing.
Successful delivery of CANTAB cognitive assessments across diverse health systems
At the virtual AAIC 2020 conference Dr Elizabeth Baker presented data on the successful delivery of CANTABTM assessments across diverse health systems and ages: 10 – 90 years old.
The study captures normative performance across the lifespan to support a cognitive screening tool for characterising a range of neuropsychological disorders in clinics across India.
COVID-19 and Virtual Trials: What does the FDA’s guidance mean for drug development?
The FDA have released guidance urging clinical trials to go virtual where possible in response to the COVID-19 pandemic – so what are the best methods for ensuring patient safety and trial integrity during this transition? In this article, we will discuss some of the important aspects to consider when taking a therapeutic trial from the clinic to the patient’s home.
The full FDA Guidance on Conduct of Clinical Trials of Medical Products During the COVID-19 Pandemic is available here.
Cambridge Cognition wins significant new digital health contract worth £1.3m
Cambridge Cognition has announced a significant new contract providing digital health technologies to a major pharmaceutical company for application in a clinical stage development programme.
What is the value of objectively measuring emotional bias?
A negative, perceptual bias is associated with the onset and maintenance of mood disorders, and is therefore a therapeutic avenue of interest. Here we will discuss the launch of an objective assessment of emotional bias as a potential biomarker of mood.
Bringing a drug to market: How do we find and monitor suitable patients?
What will happen when we eventually develop a treatment that halts the development of early Alzheimer’s disease? Being first-in-class, pharmacovigilance post-marketing will be vitally important to ascertain the long-term effects of the drug: both positive and negative. We need to be prepared for a breakthrough and pre-emptively identify technologies which can find the right patients likely to benefit from the drug and monitor treatment effects in the real world.
How can you measure behavior more accurately in your clinical trials?
Drug development typically relies upon clinical endpoints established within very controlled laboratory environments. Digital health technologies now provide the opportunity to transition data collection from the clinic into people’s personal lives, thereby providing more accurate conclusions about how a compound can influence their day-to-day life.
Does using digital health in clinical trials generate real-world outcomes?
High-frequency digital health assessments can not only characterize clinically-relevant data as it occurs in real-time, but capture this information within the patient’s home environment. Therefore, digital health platforms provide an ecologically valid data source which directly maps on to an individual’s daily functioning and real-world outcomes.
Can digital health reduce the treatment burden on patients?
Comprehensive neuropsychological testing typically takes hours to complete, which can be mentally and physically burdensome for patients. Furthermore, the travel required and overall time-commitment to undergo these procedures within a clinic can result in decreased study compliance. Together these factors can confound conclusions concerning treatment efficacy. Here we will discuss how digital health can reduce these burdens when implementing therapeutic interventions to improve patient outcomes.
Four reasons to use digital health in your clinical trials
In the first of our digital health series we will outline what the term means, and the opportunities offered, within the context of clinical trials in psychiatry.
How can digital health improve the signal-to-noise ratio in your clinical trials?
The contemporary framework for designing clinical trials is to build a comprehensive cognitive profile of the patient population from thorough but infrequent assessments. However, this framework struggles to capture the daily fluctuations in mood and cognition that many individuals with psychiatric disorders experience. Here we will discuss how the advent of digital health offers the opportunity to capture a more holistic representation of patients’ cognitive function from high-frequency assessments.
NeuroVocalix platform ready for clinical trials
NeuroVocalix enables novel voice-based cognitive assessments to be delivered directly to patients through mobile and tele-health platforms, helping to improve outcomes in clinical trials, aid clinical decision-making and play an important role in the management of long-term conditions such as chronic pain.
What is the optimal approach for using digital cognitive biomarkers in clinical trials?
Digital cognitive biomarkers are typically active or passive: but which approach enhances clinical trial success? Here we will define how active and passive cognitive biomarkers function in clinical trials, to conclude their optimal application.
What are digital cognitive biomarkers and why are they useful?
Biomarkers are important for the detection of disease-relevant information to help recruit, stratify and monitor patients, and to evaluate the safety and efficacy of compounds. Here we’ll discuss what digital biomarkers are and how they offer an opportunity to revolutionize research and drug development in psychiatric and neurological disorders.
How can employers promote mental health at work?
Mental wellbeing is integral to the health and functioning of the workforce, the compromise of which can have serious social and financial ramifications - but what actions can employers take to promote mental wellbeing?
Healthy Amplified launch new population health platform with CANTAB technology
Healthy Amplified are using CANTAB® technology to expand their population health platform offering to adults.
Neural Network classification of longitudinal cognitive data for prediction of individual-level chan
For the first time, Neural Network classifiers have been applied to changes in CANTAB PAL performance between baseline and 10 months to accurately predict the development of MCI at 20 months. Dr Elizabeth Baker, Statistical Scientist at Cambridge Cognition, presented the novel findings at AAIC 2018.
CANTAB BrainHealth offers benefits for healthcare professionals, employers and employees
We caught up with brain health and workplace mental performance consultant, Dr Jenny Brockis, on how tools like CANTAB BrainHealth can be used to promote mental wellbeing at work.
CANTAB technology selected for world’s largest dementia study
We are pleased to announce our partnership with Dementias Platform UK (DPUK), the world’s largest study group in dementia research formed to accelerate the development of effective, and ultimately preventative, treatments for diseases such as Alzheimer’s.
New product to improve workplace mental health
We are very pleased to announce a planned new software product to assess mental health and wellbeing at work, CANTAB BrainHealth™.
New client signs with Cognition Kit software
We’re delighted to announce a new $0.5m contract with a major pharmaceutical company for the use of our Cognition Kit digital health software in a clinical trial.
Pen-and-paper vs. computerised testing: which method do older adults prefer?
Exciting new research shows not only that web-based cognitive assessments are suitable for older adults but, for many, computerised assessments are actually preferable to traditional pen-and-paper tasks.
