The BUMP Study: Using digital tools to gain a deeper understanding of pregnancy symptoms
Earlier this year, members of the Cambridge Cognition team were co-authors on a paper describing a protocol for the Better Understanding the Metamorphosis of Pregnancy (BUMP) study. This study, led by 4YouandMe, is aiming to use digital tools, some of which are provided by Cambridge Cognition, to gain a deeper understanding of the symptoms of pregnancy. Here, we explain the study's aims and why it is important. You can find the full paper here.
Measuring functional outcomes in schizophrenia in an increasingly digital world
In this paper published in Schizophrenia Research: Cognition in April 2022, we explore how digital outcome assessments could be beneficial for assessing functional outcomes for people affected by schizophrenia. Read the full paper here.
Remote symptom monitoring using wearable technology
Capturing daily fluctuations in mood and cognition can help to more accurately monitor treatment response - but is this feasible for patients with depression?
In research presented at CNS2020, we examined the feasibility of high-frequency cognitive assessments, and their relationship with daily measures of depressive symptoms and physical activity.
Bringing a drug to market: How do we find and monitor suitable patients?
What will happen when we eventually develop a treatment that halts the development of early Alzheimer’s disease? Being first-in-class, pharmacovigilance post-marketing will be vitally important to ascertain the long-term effects of the drug: both positive and negative. We need to be prepared for a breakthrough and pre-emptively identify technologies which can find the right patients likely to benefit from the drug and monitor treatment effects in the real world.
How can you measure behavior more accurately in your clinical trials?
Drug development typically relies upon clinical endpoints established within very controlled laboratory environments. Digital health technologies now provide the opportunity to transition data collection from the clinic into people’s personal lives, thereby providing more accurate conclusions about how a compound can influence their day-to-day life.
Does using digital health in clinical trials generate real-world outcomes?
High-frequency digital health assessments can not only characterize clinically-relevant data as it occurs in real-time, but capture this information within the patient’s home environment. Therefore, digital health platforms provide an ecologically valid data source which directly maps on to an individual’s daily functioning and real-world outcomes.
Can digital health reduce the treatment burden on patients?
Comprehensive neuropsychological testing typically takes hours to complete, which can be mentally and physically burdensome for patients. Furthermore, the travel required and overall time-commitment to undergo these procedures within a clinic can result in decreased study compliance. Together these factors can confound conclusions concerning treatment efficacy. Here we will discuss how digital health can reduce these burdens when implementing therapeutic interventions to improve patient outcomes.
Four reasons to use digital health in your clinical trials
In the first of our digital health series we will outline what the term means, and the opportunities offered, within the context of clinical trials in psychiatry.
How can digital health improve the signal-to-noise ratio in your clinical trials?
The contemporary framework for designing clinical trials is to build a comprehensive cognitive profile of the patient population from thorough but infrequent assessments. However, this framework struggles to capture the daily fluctuations in mood and cognition that many individuals with psychiatric disorders experience. Here we will discuss how the advent of digital health offers the opportunity to capture a more holistic representation of patients’ cognitive function from high-frequency assessments.
Wearable devices: the future for near-patient testing?
Cognition Kit and Takeda have collaborated to deliver high frequency assessments of mood and cognition in major depressive disorder, using the Apple Watch.
Takeda and Cognition Kit partner to pilot wearables in patients with Major Depressive Disorder (MDD)
Takeda Pharmaceuticals U.S.A. and Cognition Kit Limited announce a collaboration to pilot the use of a specially designed app on an Apple Watch wearable to monitor and assess cognitive function in patients with Major Depressive Disorder (MDD).