Mild Cognitive Impairment (MCI) is a heterogeneous condition with differential underlying pathophysiologies. The objective of this research, presented at AAIC 2015, was to examine the relationship between performance on the CANTAB tasks probing hippocampal and fronto-striatal function, hippocampal volume and CSF biomarkers.
In this study, the relationships between biomarkers and cognitive task performance was assessed through a series of linear regression models using LM in R software. All models were adjusted for age and years of education. Differences between CSF-POS and CSF-NEG group were assessed using t-tests or Chi-squared tests.
At baseline, CSF-POS individuals showed worse performance relative to CSF-NEG individuals on fronto-striatal dependent recognition and working memory tasks (i.e. SRM, DMS and SWM), with effect sizes ranging from -0.12 to -0.66. Worse performance on the Paired Associate Learning (PAL) task of episodic memory was associated with reduced hippocampal volume, higher CSF levels of tau and p-tau and increased Tau/Abeta42 ratio.
Interested in learning more about the characterisation of cognitive function in individuals with amnestic MCI? Download this poster.