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Differential effects of APOE and CSF Amyloid on Memory Impairment

Carriage of the apolipoprotein E (APOE) ɛ4 allele and accumulation of beta-amyloid (Aβ) in the brain are both strong risk factors for Alzheimer’s disease (AD) and linked to greater cognitive decline. The effect of these risk factors on cognitive impairment is less clear in individuals with amnestic mild cognitive impairment (aMCI).


In this research, presented at AAIC 2016, we examined cognitive function at a single time point (i.e. baseline) in individuals with aMCI who were Aβ+ and Aβ- as well as APOE ɛ4 carriers ((ɛ4+) with at least one copy of the ɛ4 allele) and non-carriers (ɛ4-).

In total, 145 individuals underwent clinical and cognitive evaluation using the CANTAB tests, high resolution 3T MRI with MPRAGE and lumbar punctures for the assessment of cerebrospinal fluid (CSF) levels of Aβ42, tau and p-tau.


Findings from the current study suggest that aMCI is associated with a diverse profile of memory impairment with independent and interactive modulation by Aβ and APOE ɛ4 status even at a single time point, supporting observations from previous cross-sectional studies.

Interested in learning more about the differential effects of APOE and CSF amyloid on memory impairment in individuals with aMCI? Download this poster. 


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