The initial clinical diagnosis of mild cognitive impairment (MCI) can be unstable, with the degree of cognitive impairment rapidly worsening in some people, and apparently resolving in others. This research, showcased at AAIC 2015, used a computerised measure of paired associate learning (CANTAB PAL) to predict stable versus transient MCI.
Participants were recruited from a longitudinal study of neuropsychological function in community-residing adults with suspected MCI. Study participants underwent CANTAB PAL testing at baseline and ten months later. At 20 months patients were reassessed and the diagnostic process was repeated.
At both baseline and follow-up, PAL performance was significantly worse in a-MCI patients compared to all other groups, which were not significantly different from each other. This included participants initially diagnosed with a-MCI which then resolved.
Interested in learning more about the use of PAL as a predictor of a consistent diagnosis of the stability of amnestic MCI? Download this poster.