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Characterization Of Cognitive Decline Over 5 Years in an Incident Parkinson’s Disease Cohort

Parkinson’s disease (PD) is associated with a significant cognitive decline that affects multiple domains. In a population-representative, incident PD cohort (CamPaIGN), we previously reported a cumulative dementia incidence of 46% over ten years.

In this research, presented at AD/PD 2015, we report in more detail how cognitive performance in multiple domains changes over the first five years, from diagnosis in a more cognitively able subgroup of the CamPaIGN cohort and assess the effects of the medication and relationship with day-to-day function.


As part of this study, 142 participants were assessed on the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Schwab & England (S&E) Activities of Daily Living Scale. Participants also carried out a neuropsychological assessment which included the Mini Mental State Examination (MMSE), computerised CANTAB tests (SRM, PRM, and OTS).


At baseline, there was a significant difference in age and MMSE between the completer cohort and the group as a whole. In the completer subgroup, there were significant time-dependent deteriorations in semantic fluency, SRM and OTS with effect sizes of moderate magnitude (d= -0.36 to -0.49). There were no significant changes in phonemic fluency or PRM.

Interested in learning more about the characterisation of cognitive decline in an incident PD cohort? Download this poster. 

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