Login
Facebook YouTube Twitter Linkedin
Facebook YouTube Twitter Linkedin

Characterization Of Cognitive Decline Over 5 Years in an Incident Parkinson’s Disease Cohort

Parkinson’s disease (PD) is associated with a significant cognitive decline that affects multiple domains. In a population-representative, incident PD cohort (CamPaIGN), we previously reported a cumulative dementia incidence of 46% over ten years.

In this research, presented at AD/PD 2015, we report in more detail how cognitive performance in multiple domains changes over the first five years, from diagnosis in a more cognitively able subgroup of the CamPaIGN cohort and assess the effects of the medication and relationship with day-to-day function.

Methods

As part of this study, 142 participants were assessed on the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Schwab & England (S&E) Activities of Daily Living Scale. Participants also carried out a neuropsychological assessment which included the Mini Mental State Examination (MMSE), computerised CANTAB tests (SRM, PRM, and OTS).

Results

At baseline, there was a significant difference in age and MMSE between the completer cohort and the group as a whole. In the completer subgroup, there were significant time-dependent deteriorations in semantic fluency, SRM and OTS with effect sizes of moderate magnitude (d= -0.36 to -0.49). There were no significant changes in phonemic fluency or PRM.

Interested in learning more about the characterisation of cognitive decline in an incident PD cohort? Download this poster. 

Download here

Share this