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Psychometric properties of cognitive endpoints from the CANTAB neuropsychological battery

This study, the results of which we presented at CTAD 2016, looked at the traditional psychometric properties of CANTAB tests for use in a prodromal Alzheimer's disease population.

Recent research has documented the psychometric properties of neuropsychological tests and primary endpoints commonly used in clinical trials and studies of prodromal Alzheimer’s disease (pAD). Here we extended this analysis to include a broader range of cognitive measures using the CANTAB neuropsychological battery that taps into distinct aspects of cognition.

Methods

The properties of the CANTAB tasks were evaluated using traditional psychometric methods, including floor and ceiling effects, test-retest reliability and construct validity, at screening and baseline (up to eight weeks apart).

CANTAB neuropsychological assessment tasks included: PAL, SWM, PRM, DMS, RVP and RTI. Assessment of bias and limits of agreement were established using the Bland and Altman method for reliability of measures.

Results

Test re-test (Screening to Baseline) was good for episodic memory (PAL), processing speed (RTI), sustained attention (RVP) and the composite memory score ranging from 0.63 to 0.76. Test re-test was lower for DMS and PRM, the latter partly reflecting the change in performance (ceiling effects) from Screening to Baseline.

The CANTAB tasks are a suitable assessment tool for pAD subjects enabling robust measurement across the ability range and sensitivity to early cognitive decline and disease progression.

Interested in learning more about the psychometric properties of cognitive endpoints from the CANTAB test battery in a prodromal Alzheimer’s disease population? Download this poster.

 

Download here

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