Login
Facebook YouTube Twitter Linkedin
Facebook YouTube Twitter Linkedin

The Deep and Frequent Phenotyping (DFP) CANTAB cognitive assessment from the feasibility study

The Deep and Frequent Phenotyping Study (DFP) is a multi-centre, observational study of prodromal Alzheimer’s disease (AD) and forms part of the Dementias Platform UK.

The study includes a wide range of established and novel biomarkers and aims to identify a set of multi-modal markers for phenotyping prodromal AD, as part of the study, CANTAB cognitive tests are being used at multiple time points to assess changes in cognitive function.

This research, presented at the DFP-DPUK 2017 conference, details the results of the CANTAB tests from the pilot project for the study.

Methods

Pilot data were collected at six centres (Oxford, Cambridge, Newcastle, University College London, Imperial College and Kings College London).

In total, 22 participants (M= 10, F=12) completed screening assessments and 19 were followed up to Day 160. Age ranged from 54 to 84 years. Participants were classified as early AD (NIA-AA) with MMSE >20, with a Rosen Modified Hachinski Ischemic score of <4.

Cognition, measured with the CANTAB battery covered the following cognitive domains: episodic memory (PAL), working memory (SWM), sustained attention (RVP) and process speed (RTI).

Results

The CANTAB tasks were well-tolerated by participants with a high completion rate. Cognitive profiles reflected those expected for an early AD sample. The pilot results also showed sensitivity to decline in performance over six months. Overall, the CANTAB computerised platform provided a validated, sensitive cognitive testing tool for assessment in prodromal AD.

Interested in learning more about the use of CANTAB cognitive assessments in the Deep and Frequent Phenotyping (DFP) pilot study? Download this poster.

 

Download here

Share this