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23 August 2019

Why is it important to assess cognitive safety in oncology trials?

Following steady improvements in survival rates, there is a growing interest in establishing the long-term side effects of cancer treatments. This includes a need for a better understanding of the cognitive safety profile of these interventions, particularly in children and adolescents. In this article, we demonstrate that CANTAB computerised assessments offer a sensitive and practical solution for assessing cognitive function in oncology trials.

15 August 2019

Does low-level exposure to lead and manganese affect cognition and behaviour?

The Salud Ambiental Montevideo cohort is characterised by several social-environmental factors, including exposure to metals and cognitive performance. We caught up with Seth Frndak from the University of Buffalo to talk through CANTAB’s role in this epidemiological study.  

13 August 2019

Why does the largest twins registry in the UK use CANTAB?

TwinsUK has been using CANTAB for the last 10 years to enable their multi-modal, longitudinal research into typical and pathological ageing. We caught up with the Project Coordinator, Taha Bhatti, to discuss the cohort’s experience of completing the tasks, and transitioning to web-based delivery. 

6 August 2019

Using CANTAB to enhance pro-cognitive clinical trials in multiple sclerosis

Accurate outcome measures and suitable patient recruitment will be vital to the success of pro-cognitive treatment trials in multiple sclerosis (MS). In this article, we highlight the sensitivity of various CANTAB tasks to cognitive dysfunction in MS, and discuss the advantages of using these computerised assessments over paper-and-pencil based tests. We also consider how CANTAB tasks can be used to screen prospective participants for specific types and severities of cognitive impairment in order to gauge their suitability for inclusion in pro-cognitive intervention trials.

18 July 2019

Interim Analysis of Online Screening as a Recruitment Strategy for the Models of Patient Engagement in Alzheimer’s disease (MOPEAD) Initiative

At AAIC 2019 we presented an interim analysis of online screening as a recruitment strategy for the MOPEAD initiative. The initial findings are positive, with high levels of engagement from older adults, as well as sensitivity to impairment. 

18 July 2019

Large-Scale Remote Assessment of Verbal Cognitive Function Using Automatic Speech Recognition

At AAIC 2019, we shared how to administer and score verbal neuropsychological assessments on participants own devices in a way that is acceptable, feasible and reliable.

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